alpha Karyopherins

Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.

Also Known As:

Importin-alpha; Karyopherin alpha; NLS Receptor; NLS-Binding Protein; NLSBP; Nuclear Localization Sequence Receptor; Nuclear Localization Signal-Binding Protein; Karyopherins, alpha; receptor, NLS

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Membrane Transport Proteins: 606
      - Nucleocytoplasmic Transport Proteins: 2
        Karyopherins: 356
        alpha Karyopherins: 36
  - Membrane Proteins: 10262
    - Membrane Transport Proteins: 606
      - Nucleocytoplasmic Transport Proteins: 2
        Karyopherins: 356
        alpha Karyopherins: 36
  - Nuclear Proteins: 2740
    - Karyopherins: 356
      - alpha Karyopherins: 36

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Disease

Drug/Important Bio-Agent (IBA)